Repeated Episodes of Hypoglycemia as a Potential Aggravating Factor for Preclinical Atherosclerosis in Subjects With Type 1 Diabetes

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Repeated Episodes of Hypoglycemia as a Potential Aggravating Factor for Preclinical Atherosclerosis in Subjects With Type 1 Diabetes

OBJECTIVE To evaluate through early preclinical atherosclerosis assessment whether repeated episodes of hypoglycemia represent an aggravating factor for macrovascular disease in type 1 diabetes. RESEARCH DESIGN AND METHODS After sample-size calculation, a case-control study of 25 patients with type 1 diabetes and repeated severe/nonsevere hypoglycemia (H-group) compared with 20 age- and sex-m...

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Repeated episodes of hypoglycemia as a potential aggravating factor for preclinical atherosclerosis in subjects with T1D

This is an uncopyedited electronic version of an article accepted for publication in Diabetes Care. The American Diabetes Association, publisher of Diabetes Care, is not responsible for any errors or omissions in this version of the manuscript or any version derived from it by third parties. The definitive publisherauthenticated version will be available in a future issue of Diabetes Care in pr...

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Designing a glycemic control strategy to maintain glucose homeostasis and prevent hypoglycemia for subjects with type 1 diabetes

This paper presents using the fractional PImDn controller module which manipulates insulin infusion rate to maintain normoglycemia in subjects with type 1 diabetes. To prevent severe hypoglycemia, a conventional proportional controller is used to regulate glucagon infusion rate when the blood glucose levels fall below a threshold. Two sets of controller parameters are obtained and evaluated. Fo...

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Frequency of Diabetic Ketoacidosis and Severe Hypoglycemia in Children with Type 1 Diabetes

Background and Objective: Diabetic ketoacidosis and severe hypoglycemia are common and recurrent acute complications of type 1 diabetes and are associated with high mortality and morbidity. The aim of this study was to determine the frequency of diabetic ketoacidosis and hypoglycemia in children with type 1 diabetes. Methods: In this retrospective cross-sectional study, 480 patients with type 1...

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ژورنال

عنوان ژورنال: Diabetes Care

سال: 2010

ISSN: 0149-5992,1935-5548

DOI: 10.2337/dc10-1371